Endogenous opiates and behavior: 2006

RJ Bodnar - Peptides, 2007 - Elsevier
This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Role of hemokinin-1 in health and disease

É Borbély, Z Helyes - Neuropeptides, 2017 - Elsevier
Abstract Hemokinin-1 (HK-1), the newest tachykinin encoded by the Tac4 gene was
discovered in 2000. Its name differs from that of the other members of this peptide family due …

Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model

SY Lv, YJ Qin, NB Wang, YJ Yang, Q Chen - Peptides, 2012 - Elsevier
Apelin, as the endogenous ligand of the APJ receptor, is a novel identified neuropeptide
whose biological functions are not fully understood. APJ receptor mRNA was found in …

Aprepitant sensitizes acute myeloid leukemia cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo

H Wu, X Cheng, F Huang, G Shao, Y Meng… - Drug Design …, 2020 - Taylor & Francis
Purpose Acute myeloid leukemia (AML) is a complex malignancy characterized by the
clonal expansion of immature myeloid precursors. The standard treatment for newly …

[HTML][HTML] Hemokinin-1 gene expression is upregulated in microglia activated by lipopolysaccharide through NF-κB and p38 MAPK signaling pathways

A Sakai, K Takasu, M Sawada, H Suzuki - PloS one, 2012 - journals.plos.org
The mammalian tachykinins, substance P (SP) and hemokinin-1 (HK-1), are widely
distributed throughout the nervous system and/or peripheral organs, and function as …

Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain

C Parenti, G Aricò, G Ronsisvalle, GM Scoto - Peptides, 2012 - Elsevier
The neuropeptide Substance P (SP), that has a high affinity for the neurokinin 1 (NK1)
receptor, is involved in modulation of pain transmission. Although SP is thought to have …

[HTML][HTML] Hemokinin-1 (4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice

CY Fu, RL Xia, TF Zhang, Y Lu, SF Zhang, ZQ Yu, T Jin… - PloS one, 2014 - journals.plos.org
Our previous studies have shown that an active fragment of human tachykinins (hHK-1 (4-
11)) produced an opioid-independent analgesia after intracerebroventricular (icv) injection …

In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1 (4-11), mammalian tachykinin peptides, on the modulation of pain in mice

CY Fu, YL Zhao, L Dong, Q Chen, JM Ni… - Brain, Behavior, and …, 2008 - Elsevier
Human hemokinin-1 (h HK-1) and its truncated form h HK-1 (4-11) are mammalian
tachykinin peptides encoded by the recently identified TAC4 gene in human, and the …

Intracerebroventricular fluvoxamine administration inhibited pain behavior but increased Fos expression in affective pain pathways

T Hayashi, M Miyata, T Nagata, Y Izawa… - Pharmacology …, 2009 - Elsevier
Anti-nociceptive effects of fluvoxamine, administered by intracerebroventricular (icv)
injection, include inhibited pain behavior in both formalin-induced acute pain (p< 0.05–0.01) …

Study on the distribution sites and the molecular mechanism of analgesia after intracerebroventricular injection of rat/mouse hemokinin-1 in mice

RL Xia, CY Fu, SF Zhang, YT Jin, FK Zhao - Peptides, 2013 - Elsevier
Hemokinin-1 is a peptide encoded by Pptc, which belongs to the family of mammalian
tachykinins. Our previous results showed that rat/mouse hemokinin-1 (r/m HK-1) produced …