Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are
responsible for various aspects of T-cell immune regulation. The family includes CD28 …

Immune checkpoint blockade (ICB) therapy frequently induces immune-related adverse
events. To elucidate the underlying immunobiology, we performed a deep immune analysis …

Therapeutic vaccines preferentially stimulate T cells against tumour-specific epitopes that
are created by DNA mutations or oncogenic viruses. In the setting of premalignant disease …

Intratumoral regulatory T (Treg) cell abundance associates with diminished antitumor
immunity and poor prognosis in human cancers. Recent work demonstrates that CD25, the …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a
target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …

Generating an anti-tumor immune response is a multi-step process that is executed by
effector T cells that can recognize and kill tumor targets. However, tumors employ multiple …

It is well known that many tumours are potentially immunogenic, as corroborated by the
presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous …

Tumours express a range of antigens, including self-antigens. Regulatory T cells are crucial
for maintaining T-cell tolerance to self-antigens. Regulatory T cells are thought to dampen T …