Antibiotics target energy-consuming processes. As such, perturbations to bacterial metabolic
homeostasis are significant consequences of treatment. Here, we describe three postulates …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

Current machine learning techniques enable robust association of biological signals with
measured phenotypes, but these approaches are incapable of identifying causal …

Understanding how antibiotics impact bacterial metabolism may provide insight into their
mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we …

Microbial metabolomics focuses on the analysis of intracellular or extracellular primary
metabolites, signaling molecules, hormones, and secondary metabolites, and it is an …

Highlights What are the main findings? Hypothesis: Redox, bioenergetic and temperature
regulation is critical in maintaining cellular circadian rhythms; wakefulness is mainly …

Bacterial persisters are rare phenotypic variants that temporarily tolerate high antibiotic
concentrations. Persisters have been hypothesized to underlie the recalcitrance of biofilm …

Escherichia coli strains are widely used in academic research and biotechnology. New
technologies for quantifying strain-specific differences and their underlying contributing …

Metabolically quiescent bacteria represent a large proportion of those in natural and host
environments, and they are often refractory to antibiotic treatment. Such drug tolerance is …

Roughly half the carbon that crop plants fix by photosynthesis is subsequently lost by
respiration. Nonessential respiratory activity leading to unnecessary CO2 release is unlikely …