CGRP as the target of new migraine therapies—successful translation from bench to clinic

L Edvinsson, KA Haanes, K Warfvinge… - Nature Reviews …, 2018 - nature.com
Abstract Treatment of migraine is on the cusp of a new era with the development of drugs
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …

[HTML][HTML] Neurogenic inflammation: the participant in migraine and recent advancements in translational research

E Spekker, M Tanaka, Á Szabó, L Vécsei - Biomedicines, 2021 - mdpi.com
Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Targeting CGRP for migraine treatment: mechanisms, antibodies, small molecules, perspectives

E De Matteis, M Guglielmetti, R Ornello… - Expert review of …, 2020 - Taylor & Francis
ABSTRACT Introduction Calcitonin Gene-Related Peptide (CGRP) has gradually emerged
as a suitable therapeutic target to treat migraine. Considering the social and economic …

[HTML][HTML] TRPV1: a common denominator mediating antinociceptive and antiemetic effects of cannabinoids

K Louis-Gray, S Tupal, LS Premkumar - International Journal of Molecular …, 2022 - mdpi.com
The most common medicinal claims for cannabis are relief from chronic pain, stimulation of
appetite, and as an antiemetic. However, the mechanisms by which cannabis reduces pain …

[HTML][HTML] TRP channels in the focus of trigeminal nociceptor sensitization contributing to primary headaches

M Dux, J Rosta, K Messlinger - International journal of molecular sciences, 2020 - mdpi.com
Pain in trigeminal areas is driven by nociceptive trigeminal afferents. Transduction
molecules, among them the nonspecific cation channels transient receptor potential …

Gastric protective effect of Alpinia officinarum flavonoids: mediating TLR4/NF-κB and TRPV1 signalling pathways and gastric mucosal healing

K Lin, T Deng, H Qu, H Ou, Q Huang, B Gao… - Pharmaceutical …, 2023 - Taylor & Francis
Context Our previous studies have found that total flavonoid of Alpinia officinarum Hance
(Zingiberaceae)(F. AOH) had protective effects on gastric ulcer (GU). Objective To …

Implications of transient receptor potential cation channels in migraine pathophysiology

M Shibata, C Tang - Neuroscience bulletin, 2021 - Springer
Migraine is a common and debilitating headache disorder. Although its pathogenesis
remains elusive, abnormal trigeminal and central nervous system activity is likely to play an …

[HTML][HTML] Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells

T Grüter, A Blusch, J Motte, M Sgodzai, H Bachir… - Journal of …, 2020 - Springer
Background Only few studies describe the impact of nutritive factors on chronic inflammatory
demyelinating polyneuropathy (CIDP), an inflammatory disease of the peripheral nervous …

[HTML][HTML] A TRiP through the roles of transient receptor potential cation channels in type 2 upper airway inflammation

W Backaert, B Steelant, PW Hellings… - Current Allergy and …, 2021 - Springer
Abstract Purpose of Review Despite their high prevalence, the pathophysiology of allergic
rhinitis (AR) and chronic rhinosinusitis (CRS) remains unclear. Recently, transient receptor …

[HTML][HTML] Antagonism of transient receptor potential ankyrin type-1 channels as a potential target for the treatment of trigeminal neuropathic pain: study in an animal …

C Demartini, R Greco, AM Zanaboni… - International journal of …, 2018 - mdpi.com
Transient receptor potential ankyrin type-1 (TRPA1) channels are known to actively
participate in different pain conditions, including trigeminal neuropathic pain, whose clinical …