In recent years, high-throughput lipid profiling has contributed to understand the biological,
physiological and pathological roles of lipids in living organisms. Across all kingdoms of life …

We demonstrated the metabolic benefits of Parabacteroides distasonis (PD) on decreasing
weight gain, hyperglycemia, and hepatic steatosis in ob/ob and high-fat diet (HFD)-fed mice …

Antidiabetic medication may modulate the gut microbiota and thereby alter plasma and
faecal bile acid (BA) composition, which may improve metabolic health. Here we show that …

Enhanced de novo lipogenesis mediated by sterol regulatory element–binding proteins
(SREBPs) is thought to be involved in nonalcoholic steatohepatitis (NASH) pathogenesis. In …

Bile acids (BAs) are important regulatory factors of life activities, which are involved in the
regulation of glucose, lipid and energy metabolisms, and closely associated with intestinal …

Adaptive thermogenesis is an energy-demanding process that is mediated by cold-activated
beige and brown adipocytes, and it entails increased uptake of carbohydrates, as well as …

Bile acids are important end products of cholesterol metabolism. While they have been
identified as key factors in lipid emulsification and absorption due to their detergent …

Non-alcoholic steatohepatitis (NASH) is a highly prevalent chronic liver disease. Here, we
have investigated whether BAR502, a non-bile acid, steroidal dual ligand for FXR and …

Ethnopharmacological relevance Radix scutellariae (the root of Scutellaria baicalensis
Georgi), is a traditional Chinese medicine (TCM) used to treat type 2 diabetes mellitus …

Due to the exceptional laying performance of hens, the demand on lipid metabolism and
oxidation in vivo is vigorous, resulting in excessive lipid accumulation in late-phase hens …