Muscles are essential for movement and heart function. Contraction and relaxation of
muscles rely on the sliding of two types of filaments—the thin filament and the thick myosin …

The thick filament is a key component of sarcomeres, the basic units of striated muscle.
Alterations in thick filament proteins are associated with familial hypertrophic …

Muscles generate forces for animal locomotion. The contractile apparatus of muscles is the
sarcomere, a highly regular array of large actin and myosin filaments linked by gigantic titin …

Heart muscle has the unique property that it can never rest; all cardiomyocytes contract with
each heartbeat which requires a complex control mechanism to regulate cardiac output to …

The atomic structure of the complete myosin tail within thick filaments isolated from
Lethocerus indicus flight muscle is described and compared to crystal structures of …

Sarcomeres are the force-producing units of all striated muscles. Their nanoarchitecture
critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z …

The thick filament is a key component of sarcomeres, the basic force-generating and load-
bearing unit of striated muscle. Mutations in thick filament proteins are associated with …

Striated muscle thick filaments are composed of myosin II and several non-myosin proteins
which define the filament length and modify its function. Myosin II has a globular N-terminal …

The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to
contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to …

Myosins are a superfamily of ATP-driven actin-dependent molecular motors that are
responsible for diverse functions from muscle contraction to cell division. The resolution …