The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

K+ channel principal subunits are by far the largest and most diverse of the ion channels.
This diversity originates partly from the large number of genes coding for K+ channel …

Ion channels represent the molecular entities that give rise to the cardiac action potential,
the fundamental cellular electrical event in the heart. The concerted function of these …

Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …

Abstract M-type (KCNQ2/3) potassium channels are suppressed by activation of Gq/11-
coupled receptors, thereby increasing neuronal excitability. We show here that rat KCNQ2 …

Cerebellar granule neurons (CGNs) are one of the most populous cells in the mammalian
brain. They express an outwardly rectifying potassium current, termed a “standing-outward” …

Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …

Plant voltage‐gated channels belonging to the Shaker family participate in sustained K+
transport processes at the cell and whole plant levels, such as K+ uptake from the soil …

As molecular docking poses a challenging problem in rational drug design many
workgroups have lavished their attention on finding and testing various docking techniques …