Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

Vascular anomalies are malformations or tumors of the blood or lymphatic vasculature and
can be life-threatening. Although molecularly targeted therapies can be life-saving …

Gorham-Stout disease (GSD) is a sporadically occurring lymphatic disorder. Patients with
GSD develop ectopic lymphatics in bone, gradually lose bone, and can have life-threatening …

Central conducting lymphatic anomaly (CCLA) due to congenital maldevelopment of the
lymphatics can result in debilitating and life-threatening disease with limited treatment …

Background Kaposiform lymphangiomatosis (KLA) is a complex lymphatic anomaly
involving most commonly the mediastinum, lung, skin and bones with few effective …

The lymphatic vascular system is gaining recognition for its multifaceted role and broad
pathological significance. Once perceived as a mere conduit for interstitial fluid and immune …

Objective To evaluate the effect of the RAS-MAPK pathway inhibitor trametinib on medically
refractory chylous effusions in 3 hospitalized patients with Noonan syndrome. Study design …

The RASopathies are a group of clinically defined developmental syndromes caused by
germline variants of the RAS/mitogen‐activated protein (MAPK) cascade. The prototypic …

Noonan syndrome (NS), the most common among RASopathies, is caused by germline
variants in genes encoding components of the RAS-MAPK pathway. Distinct variants …