Gut microbiome lipid metabolism and its impact on host physiology

EM Brown, J Clardy, RJ Xavier - Cell Host & Microbe, 2023 - cell.com
Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Human metabolome variation along the upper intestinal tract

J Folz, RN Culver, JM Morales, J Grembi… - Nature …, 2023 - nature.com
Most processing of the human diet occurs in the small intestine. Metabolites in the small
intestine originate from host secretions, plus the ingested exposome and microbial …

Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules

E Ryan, SA Joyce, DJ Clarke - Microbiology, 2023 - microbiologyresearch.org
Bacteria produce an array of diverse, dynamic and often complex lipid structures, some of
which function beyond their typical role in membrane structure. The model organism, E. coli …

Role and interaction of bacterial sphingolipids in human health

X Bai, R Ya, X Tang, M Cai - Frontiers in Microbiology, 2023 - frontiersin.org
Sphingolipids, present in both higher animals and prokaryotes, involving in cell
differentiation, pathogenesis and apoptosis in human physiological health. With increasing …

Arsinothricin Biosynthesis Involving a Radical SAM Enzyme for Noncanonical SAM Cleavage and C–As Bond Formation

Y Yao, J He, F Chen, M Dong - Journal of the American Chemical …, 2024 - ACS Publications
Arsinothricin is a potent antibiotic secreted by soil bacteria. The biosynthesis of arsinothricin
was proposed to involve a C–As bond formation between trivalent As and the 3-amino-3 …

Structure revision of a widespread marine sulfonolipid class based on isolation and total synthesis

D Roman, P Meisinger, R Guillonneau… - Angewandte Chemie …, 2024 - Wiley Online Library
The cosmopolitan marine Roseobacter clade is of global biogeochemical importance.
Members of this clade produce sulfur‐containing amino lipids (SALs) involved in biofilm …

Biosynthetic enzyme analysis identifies a protective role for TLR4-acting gut microbial sulfonolipids in inflammatory bowel disease

EA Older, J Zhang, ZE Ferris, D Xue, Z Zhong… - Nature …, 2024 - nature.com
The trillions of microorganisms inhabiting the human gut are intricately linked to human
health. While specific microbes have been associated with diseases, microbial abundance …

[HTML][HTML] A neonatal piglet model reveals interactions between nasal microbiota and influenza A virus pathogenesis

F Yuan, L Yang, SH Hsiao, NL Herndon, CA Gaulke… - Virology, 2024 - Elsevier
While vaccination and therapeutics for prevention/treatment of influenza are available, new
strategies are needed to combat influenza disease in susceptible populations, particularly …

Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii

CD Radka, DJ Miller, MW Frank, CO Rock - Journal of Biological Chemistry, 2022 - ASBMB
Sulfonolipids are unusual lipids found in the outer membranes of Gram-negative bacteria in
the phylum Bacteroidetes. Sulfonolipid and its deacylated derivative, capnine, are sulfur …

Vegetable phylloplane microbiomes harbour class 1 integrons in novel bacterial hosts and drive the spread of chlorite resistance

Q Qi, TM Ghaly, V Rajabal, DH Russell… - Science of the Total …, 2024 - Elsevier
Bacterial hosts in vegetable phylloplanes carry mobile genetic elements, such as plasmids
and transposons that are associated with integrons. These mobile genetic elements and …