Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

Toll-like receptors (TLRs) are components of the innate immune system that respond to
exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and …

Observational studies of necrotic core progression identify intraplaque hemorrhage as a
critical factor in atherosclerotic plaque growth and destabilization. The rapid accumulation of …

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Atherothrombosis is a complex disease in which cholesterol deposition, inflammation, and
thrombus formation play a major role. Rupture of high-risk, vulnerable plaques is …

One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …

Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

During physiological processes molecules undergo chemical changes involving reducing
and oxidizing reactions. A molecule with an unpaired electron can combine with a molecule …