Inspired by the biological processes of molecular recognition and transportation across
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …

Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …

The coarse-grained Martini force field is widely used in biomolecular simulations. Here we
present the refined model, Martini 3 (http://cgmartini. nl), with an improved interaction …

Direct protein sequencing technologies with improved sensitivity and throughput are still
needed. Here, we propose an alternative method for peptide sequencing based on …

Nanopores have recently been used to identify and fingerprint proteins. However, because
proteins, unlike DNA, do not have a uniform charge, the electrophoretic force cannot in …

Current methods to detect post-translational modifications of proteins, such as phosphate
groups, cannot measure single molecules or differentiate between closely spaced …

Means to analyse cellular proteins and their millions of variants at the single-molecule level
would uncover substantial information previously unknown to biology. Nanopore …

The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …

Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and
structure data have radically transformed computational protein design. New methods …

Diverse functions of proteins, including synthesis, catalysis, and signaling, result from their
highly variable amino acid sequences. The technology allowing for direct analysis of protein …