Guanidinium-based “molecular glues” for modulation of biomolecular functions
Molecular adhesion based on multivalent interactions plays essential roles in various
biological processes. Hence,“molecular glues” that can adhere to biomolecules may …
biological processes. Hence,“molecular glues” that can adhere to biomolecules may …
Engineered horseradish peroxidase-catalyzed hydrogels with high tissue adhesiveness for biomedical applications
Adhesive hydrogels offer considerable potential in biomedical applications because of the
excellent integration between materials and tissues. Horseradish peroxidase (HRP) …
excellent integration between materials and tissues. Horseradish peroxidase (HRP) …
Linear versus dendritic molecular binders for hydrogel network formation with clay nanosheets: studies with ABA triblock copolyethers carrying guanidinium ion …
ABA-triblock copolyethers 1a–1c as linear polymeric binders, in combination with clay
nanosheets (CNSs), afford high-water-content moldable supramolecular hydrogels with …
nanosheets (CNSs), afford high-water-content moldable supramolecular hydrogels with …
A transient vesicular glue for amplification and temporal regulation of biocatalytic reaction networks
Regulation of enzyme activity and biocatalytic cascades on compartmentalized cellular
components is key to the adaptation of cellular processes such as signal transduction and …
components is key to the adaptation of cellular processes such as signal transduction and …
Mussel-inspired thermoresponsive polypeptide–pluronic copolymers for versatile surgical adhesives and hemostasis
D Lu, H Wang, T Li, Y Li, F Dou, S Sun… - … applied materials & …, 2017 - ACS Publications
Inspired by marine mussel adhesive proteins, polymers with catechol side groups have
been extensively explored in industrial and academic research. Here, Pluronic L-31 …
been extensively explored in industrial and academic research. Here, Pluronic L-31 …
Reductively cleavable nanocaplets for siRNA delivery by template-assisted oxidative polymerization
A series of water-soluble telechelic dithiol monomers bearing multiple guanidinium ion
(Gu+) units in their main chains were synthesized for packaging siRNA by template-assisted …
(Gu+) units in their main chains were synthesized for packaging siRNA by template-assisted …
Transferrin-appended nanocaplet for transcellular siRNA delivery into deep tissues
Transferrin (Tf) is known to induce transcytosis, which is a consecutive endocytosis/
exocytosis event. We developed a Tf-appended nanocaplet (TfNC⊃ siRNA) for the purpose …
exocytosis event. We developed a Tf-appended nanocaplet (TfNC⊃ siRNA) for the purpose …
Intracellular photoactivation of caspase-3 by molecular glues for spatiotemporal apoptosis induction
NB Hentzen, R Mogaki, S Otake… - Journal of the American …, 2020 - ACS Publications
Caspase-3 (Casp-3) is an enzyme that efficiently induces apoptosis, a form of programmed
cell death. We report a dendritic molecular glue PCGlue that enables intracellular delivery of …
cell death. We report a dendritic molecular glue PCGlue that enables intracellular delivery of …
Adhesive photoswitch: selective photochemical modulation of enzymes under physiological conditions
We developed a water-soluble adhesive photoswitch (Glue n-Azo-SA, average n= 5) that
selectively binds to a target enzyme and photochemically modulates its enzymatic activity …
selectively binds to a target enzyme and photochemically modulates its enzymatic activity …
Boronic acid-appended molecular glues for ATP-responsive activity modulation of enzymes
K Okuro, M Sasaki, T Aida - Journal of the American Chemical …, 2016 - ACS Publications
Water-soluble linear polymers Gu m BA n (m/n= 18/6, 12/12, and 6/18) with multiple
guanidinium ion (Gu+) and boronic acid (BA) pendants in their side chains were synthesized …
guanidinium ion (Gu+) and boronic acid (BA) pendants in their side chains were synthesized …