Sauna use, sometimes referred to as “sauna bathing,” is characterized by short-term passive
exposure to high temperatures, typically ranging from 45° C to 100° C (113° F to 212° F) …

The opioids are commonly used to treat acute and severe pain. Long-term opioid
administration eventually reaches a dose ceiling that is attributable to the rapid onset of …

The antinociceptive effect of morphine and oxycodone is mediated preferentially at μ and κ
receptors, respectively. The aim of this study was to evaluate the analgesic profile of the …

The kappa opioid receptor is a constituent of the endogenous opioid analgesia system
widely expressed in somatosensory nervous pathways and also in endometrial tissues. This …

The aim of this review is to provide a potential benefit of an opioid combination at receptor
sites, based on experimental data and preliminary clinical studies where a combination of …

It has been widely accepted that repeated administration of κ-opioid receptor agonists leads
to the development of antinociceptive tolerance. The present study was designed to …

Evidence suggests that the κ‐opioid receptor (KOP‐r) system plays an important role in
cocaine addiction. Indeed, cocaine induces endogenous KOP activity, which is a …

The aim of the present study was to explore the possible role of kappa/dynorphin system in
the development of tolerance to nicotine antinociception in mice. First, we observed that …

Discussion and Conclusions: This case demonstrates buprenorphineʼs antisuicidal and
mood‐stabilizing capabilities, potentially via antagonizing κ‐opioid receptors as well as …

En todas las especialidades médicas, el uso conjunto de dos o más fármacos es más la
norma que la excepción. Este hecho tiene sus aspectos positivos, ya que en muchas …