Many interactions between microbes and their hosts are driven or influenced by glycans,
whose heterogeneous and difficult to characterize structures have led to an …

Traditional vaccine development builds on the assumption that healthy individuals have
virtually unlimited antigen recognition repertoires of receptors in B cells and T cells [the B …

Zika virus (ZIKV), a flavivirus with homology to dengue virus (DENV), is spreading to areas of
DENV hyper-endemicity. Heterologous T cell immunity, whereby virus-specific memory T …

Defining predictors of antigen-binding affinity of antibodies is valuable for engineering
therapeutic antibodies with high binding affinity to their targets. However, this task is …

The Zika virus (ZIKV) epidemic in the Americas was alarming because of its link with
microcephaly in neonates and Guillain-Barré syndrome in adults. The unusual pathologies …

The application of machine learning (ML) models to optimize antibody affinity to an antigen
is gaining prominence. Unfortunately, the small and biased nature of the publicly available …

Background Insufficient vaccine doses and the lack of therapeutic agents for yellow fever put
global health at risk, should this virus emerge from sub-Saharan Africa and South America …

Zika virus (ZIKV) acquired a special relevance due to the pandemic that occurred in the
Americas in 2015, when an important number of fetal microcephaly cases occurred. Since …

The computational methods used for engineering antibodies for clinical development have
undergone a transformation from three-dimensional structure-guided approaches to artificial …

The Zika virus (ZIKV) epidemic outbreak in Americas in 2016 attracted global attention
because of the association of the virus infection with severe birth defects such as …