Natural products: A lead for drug discovery and development
B Chopra, AK Dhingra - Phytotherapy Research, 2021 - Wiley Online Library
Natural products are used since ancient times in folklore for the treatment of various
ailments. Plant‐derived products have been recognized for many years as a source of …
ailments. Plant‐derived products have been recognized for many years as a source of …
An Insight Into the Modulatory Effects and Mechanisms of Action of Phyllanthus Species and Their Bioactive Metabolites on the Immune System
Phyllanthus species (family; Euphorbiaceae) have been intensively studied for their
immunomodulating effects due to their wide-ranging uses to treat immune-related diseases …
immunomodulating effects due to their wide-ranging uses to treat immune-related diseases …
[HTML][HTML] Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism
Dita bark (Alstonia scholaris (L.) R. Br.) is an ethnomedicine used for the management of
various ailments. This study aimed to investigate the biological properties of methanol …
various ailments. This study aimed to investigate the biological properties of methanol …
Anti-inflammatory effects of Phyllanthus amarus Schum. & Thonn. through inhibition of NF-κB, MAPK, and PI3K-Akt signaling pathways in LPS-induced human …
Background Phyllanthus amarus has been used widely in various traditional medicines to
treat swelling, sores, jaundice, inflammatory diseases, kidney disorders, diabetes and viral …
treat swelling, sores, jaundice, inflammatory diseases, kidney disorders, diabetes and viral …
Mechanistic insight into immunomodulatory effects of food-functioned plant secondary metabolites
Medicinally important plant-foods offer a balanced immune function, which is essential for
protecting the body against antigenic invasion, mainly by microorganisms …
protecting the body against antigenic invasion, mainly by microorganisms …
Licochalcone A protects the blood–milk barrier integrity and relieves the inflammatory response in LPS-induced mastitis
W Guo, B Liu, Y Yin, X Kan, Q Gong, Y Li… - Frontiers in …, 2019 - frontiersin.org
Background/Aims: Mastitis is an acute clinical inflammatory response. The occurrence and
development of mastitis seriously disturb women's physical and mental health. Licochalcone …
development of mastitis seriously disturb women's physical and mental health. Licochalcone …
Parthenolide alleviates microglia‐mediated neuroinflammation via MAPK/TRIM31/NLRP3 signaling to ameliorate cognitive disorder
M Fan, C Wang, X Zhao, Y Jiang, C Wang - International …, 2023 - Elsevier
Background and purpose Neuroinflammation, mainly mediated by microglia, is involved in
the evolution of Alzheimer's disease (AD). Parthenolide (PTL) has diverse pharmacological …
the evolution of Alzheimer's disease (AD). Parthenolide (PTL) has diverse pharmacological …
IgG subclass and Fc glycosylation shifts are linked to the transition from pre-to inflammatory autoimmune conditions
JS Buhre, M Becker, M Ehlers - Frontiers in Immunology, 2022 - frontiersin.org
A crucial factor for the development of inflammatory autoimmune diseases is the occurrence
of antibodies directed against self-tissues and structures, which leads to damage and …
of antibodies directed against self-tissues and structures, which leads to damage and …
Modulation of cell signaling pathways by Phyllanthus amarus and its major constituents: potential role in the prevention and treatment of inflammation and cancer
The causal and functional connection between inflammation and cancer has become a
subject of much research interest. Modulation of cell signaling pathways, such as those …
subject of much research interest. Modulation of cell signaling pathways, such as those …
Copper induces hepatic inflammatory responses by activation of MAPKs and NF-κB signalling pathways in the mouse
H Liu, H Guo, H Deng, H Cui, J Fang, Z Zuo… - Ecotoxicology and …, 2020 - Elsevier
The present study investigated the expressions of signalling molecules and inflammatory
cytokines involved in copper-induced inflammatory responses of the mouse liver. A total of …
cytokines involved in copper-induced inflammatory responses of the mouse liver. A total of …