Tryptophan metabolism in health and disease
C Xue, G Li, Q Zheng, X Gu, Q Shi, Y Su, Q Chu… - Cell Metabolism, 2023 - cell.com
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …
A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia
The emerging understanding of gut microbiota as 'metabolic machinery'influencing many
aspects of physiology has gained substantial attention in the field of psychiatry. This is …
aspects of physiology has gained substantial attention in the field of psychiatry. This is …
Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system
M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …
Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression
Z Li, J Lai, P Zhang, J Ding, J Jiang, C Liu… - Molecular …, 2022 - nature.com
The intricate processes of microbiota-gut-brain communication in modulating human
cognition and emotion, especially in the context of mood disorders, have remained elusive …
cognition and emotion, especially in the context of mood disorders, have remained elusive …
Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway
M Tanaka, F Tóth, H Polyák, Á Szabó, Y Mándi… - Biomedicines, 2021 - mdpi.com
The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities
MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …
characterized by episodic and often progressive mood fluctuations with manic and …
Activated Tryptophan-Kynurenine metabolic system in the human brain is associated with learned fear
MR Battaglia, C Di Fazio, S Battaglia - Frontiers in Molecular …, 2023 - frontiersin.org
Fear is widely recognized as a defensive emotion that has developed as a consequence of
its adaptive function in protecting the entire animal kingdom from danger, ensuring the …
its adaptive function in protecting the entire animal kingdom from danger, ensuring the …
The gut microbiome and mental health: advances in research and emerging priorities
The gut microbiome exerts a considerable influence on human neurophysiology and mental
health. Interactions between intestinal microbiology and host regulatory systems have now …
health. Interactions between intestinal microbiology and host regulatory systems have now …
Fifty years on: Serotonin and depression
It has been over 50 years since the original serotonin hypothesis was proposed by the
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and …
M Zhou, Y Fan, L Xu, Z Yu, S Wang, H Xu, J Zhang… - Microbiome, 2023 - Springer
Background Adolescent depression is becoming one of the major public health concerns,
because of its increased prevalence and risk of significant functional impairment and …
because of its increased prevalence and risk of significant functional impairment and …