Tryptophan metabolism in health and disease

C Xue, G Li, Q Zheng, X Gu, Q Shi, Y Su, Q Chu… - Cell Metabolism, 2023 - cell.com
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

AJ McGuinness, JA Davis, SL Dawson… - Molecular …, 2022 - nature.com
The emerging understanding of gut microbiota as 'metabolic machinery'influencing many
aspects of physiology has gained substantial attention in the field of psychiatry. This is …

Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system

M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression

Z Li, J Lai, P Zhang, J Ding, J Jiang, C Liu… - Molecular …, 2022 - nature.com
The intricate processes of microbiota-gut-brain communication in modulating human
cognition and emotion, especially in the context of mood disorders, have remained elusive …

Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway

M Tanaka, F Tóth, H Polyák, Á Szabó, Y Mándi… - Biomedicines, 2021 - mdpi.com
The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …

Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Activated Tryptophan-Kynurenine metabolic system in the human brain is associated with learned fear

MR Battaglia, C Di Fazio, S Battaglia - Frontiers in Molecular …, 2023 - frontiersin.org
Fear is widely recognized as a defensive emotion that has developed as a consequence of
its adaptive function in protecting the entire animal kingdom from danger, ensuring the …

The gut microbiome and mental health: advances in research and emerging priorities

AP Shoubridge, JM Choo, AM Martin, DJ Keating… - Molecular …, 2022 - nature.com
The gut microbiome exerts a considerable influence on human neurophysiology and mental
health. Interactions between intestinal microbiology and host regulatory systems have now …

Fifty years on: Serotonin and depression

S Jauhar, PJ Cowen… - Journal of …, 2023 - journals.sagepub.com
It has been over 50 years since the original serotonin hypothesis was proposed by the
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and …

M Zhou, Y Fan, L Xu, Z Yu, S Wang, H Xu, J Zhang… - Microbiome, 2023 - Springer
Background Adolescent depression is becoming one of the major public health concerns,
because of its increased prevalence and risk of significant functional impairment and …