Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal
viral infection. IFNs are secreted cytokines that activate a signal transduction cascade …

Inhibitors of VEGF (vascular endothelial growth factor)/VEGFR2 (vascular endothelial growth
factor receptor 2) are commonly used in the clinic, but their beneficial effects are only …

The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …

Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …

Abstract Interferome v2. 0 (http://interferome. its. monash. edu. au/interferome/) is an update
of an earlier version of the Interferome DB published in the 2009 NAR database edition …

Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment
early immune responses and contribute to protection. We hypothesized that MAIT cells may …

Hepatitis C virus (HCV) infects 3% of the world's population. Treatment of chronic HCV
consists of a combination of PEGylated interferon-α (PEG-IFN-α) and ribavirin (RBV). To …

Inflammation plays an essential role in the control of pathogens and in shaping the ensuing
adaptive immune responses. Traditionally, innate immunity has been described as a rapid …