Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Recent understanding of how the systemic environment shapes the brain throughout life has
led to numerous intervention strategies to slow brain ageing,–. Cerebrospinal fluid (CSF) …

The treatment of multiple sclerosis has been transformed by the successful development of
immunotherapies that efficiently reduce disease activity and related clinical relapses during …

Remyelination, the myelin regenerative response that follows demyelination, restores
saltatory conduction and function and sustains axon health. Its declining efficiency with …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

The factor that is most relevant and strongly associated with the clinical course of multiple
sclerosis is chronological age. Very young patients exclusively have relapsing remitting …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …