Recent advances and new strategies in Leishmaniasis diagnosis

RCF De Brito, RDO Aguiar-Soares… - Applied Microbiology …, 2020 - Springer
Leishmaniasis is a set of complex and multifaceted syndromes, with different clinical
manifestations, caused by different species of the genus Leishmania spp. that can be …

Leishmania Vesicle-Depleted Exoproteome: What, Why, and How?

S Esteves, I Costa, S Luelmo, N Santarém… - Microorganisms, 2022 - mdpi.com
Leishmaniasis, a vector-borne parasitic protozoan disease, is among the most important
neglected tropical diseases. In the absence of vaccines, disease management is …

Understanding Leishmania parasites through proteomics and implications for the clinic

S Sundar, B Singh - Expert review of proteomics, 2018 - Taylor & Francis
Introduction: Leishmania spp. are causative agents of leishmaniasis, a broad-spectrum
neglected vector-borne disease. Genomic and transcriptional studies are not capable of …

Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania …

L Tagliazucchi, A Perea-Martinez, G Fiorini… - ACS Infectious …, 2023 - ACS Publications
As the world is facing increasing difficulties to treat leishmaniasis with current therapies,
deeper investigation into the molecular mechanisms responsible for both drug resistance …

Intramuscular Immunization with a Liposomal Multi-Epitope Chimeric Protein Induces Strong Cellular Immune Responses against Visceral Leishmaniasis

M Agallou, M Margaroni, E Karagouni - Vaccines, 2023 - mdpi.com
Control of the intracellular parasite Leishmania (L.) requires the activation of strong type 1
cellular immune responses. Towards this goal, in the present study, a multiepitope chimeric …

The Experimental Proteome of Leishmania infantum Promastigote and Its Usefulness for Improving Gene Annotations

Á Sanchiz, E Morato, A Rastrojo, E Camacho… - Genes, 2020 - mdpi.com
Leishmania infantum causes visceral leishmaniasis (kala-azar), the most severe form of
leishmaniasis, which is lethal if untreated. A few years ago, the re-sequencing and de novo …

Identification of Immunoreactive Leishmania infantum Protein Antigens to Asymptomatic Dog Sera through Combined Immunoproteomics and Bioinformatics Analysis

M Agallou, E Athanasiou, M Samiotaki, G Panayotou… - PLoS …, 2016 - journals.plos.org
Leishmania infantum is the etiologic agent of zoonotic visceral leishmaniasis (VL) in
countries in the Mediterranean basin, where dogs are the domestic reservoirs and represent …

Using proteomics as a powerful tool to develop a vaccine against Mediterranean visceral leishmaniasis

S Rashidi, K Kalantar, G Hatam - Journal of Parasitic Diseases, 2018 - Springer
Visceral leishmaniasis (VL) is a tropical infectious disease, which is called Mediterranean
visceral leishmaniasis (MVL) in the Mediterranean area. In spite of many attempts, no …

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

E Harigua-Souiai, YZ Abdelkrim… - PLoS Neglected …, 2018 - journals.plos.org
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on
public health. The identification of novel drugs and targets constitutes a research priority. For …

Quantitative secretome analysis unravels new secreted proteins in Amphotericin B resistant Leishmania donovani

G Garg, V Ali, K Singh, P Gupta, A Ganguly… - Journal of …, 2019 - Elsevier
Leishmaniasis is second most neglected disease after malaria and seems to be a worldwide
concern because of increased drug resistance and non-availability of approved vaccine …