Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

Converging lines of evidence suggest that progressive accumulation of the amyloid β‐
protein (Aβ) plays a central role in the genesis of Alzheimer's disease, but it was long …

Genome-wide association studies (GWAS) have identified several risk variants for late-onset
Alzheimer's disease (LOAD),. These common variants have replicable but small effects on …

Presenilins were first discovered as sites of missense mutations responsible for early-onset
Alzheimer disease (AD). The encoded multipass membrane proteins were subsequently …

Developing effective treatments for neurodegenerative diseases is one of the greatest
medical challenges of the 21st century. Although many of these clinical entities have been …

Mutations in presenilins are the major cause of familial Alzheimer's disease, but the
pathogenic mechanism by which presenilin mutations cause memory loss and …

Dominantly inherited mutations in the genes encoding presenilins (PS) and the amyloid
precursor protein (APP) are the major causes of familial Alzheimer's disease (AD). The …

The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent
in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the …

Abstract γ-Secretase—a protease that cleaves within the membrane—was first recognized
for its role in the production of amyloidogenic Aβ peptides, but was subsequently found to …

Mutations in human presenilin (PS) genes cause aggressive forms of familial Alzheimer's
disease. Presenilins are polytopic proteins that harbour the catalytic site of the γ‐secretase …