Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …

Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine
system. There has been a significant increase in its incidence over the past two decades …

Background Immune checkpoint blockade (ICB) targeting programmed cell death protein 1
and cytotoxic T lymphocyte-associated protein 4 has achieved modest clinical activity as …

Background The role of circular RNA (circRNA) in papillary thyroid cancer (PTC) is largely
unknown. This study aims to determine the function and mechanism of circPRMT5 in the …

Abstract The Fas/FasL system plays a central role in the physiological regulation of
apoptosis and has been implicated in the pathogenesis of several neoplasms and diseases …

Although CD95L (also known as FasL) is still predominantly considered as a death ligand
that induces apoptosis in infected and transformed cells, substantial evidence indicate that it …

Purpose.: We examined the effect of aging on Fas ligand (FasL) function in a mouse model
of choroidal neovascularization (CNV). Methods.: Young and aged mice were laser treated …

Cell death is a critical biological process, serving many important functions within
multicellular organisms. Aberrations in cell death can contribute to the pathology of human …

Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumours that compose 1–2% of
all pancreatic tumours. Patients with metastatic grade 3 neoplasia are usually treated with …

Abstract Background Purpose: The combination of a mammalian target of rapamycin
inhibitor and lenalidomide showed enhanced preclinical cytotoxicity. We conducted a phase …