The two PIF1 family helicases in Saccharomyces cerevisiae, Rrm3, and ScPif1, associate
with thousands of sites throughout the genome where they perform overlapping and distinct …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and
RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non …

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1, and
RMI2 to form the BTR complex, which dissolves double Holliday junctions and DNA …

ATP-dependent RAD51 recombinases play an essential role in eukaryotic homologous
recombination by catalyzing a four-step process: 1) formation of a RAD51 single-filament …

Rad52 is a key factor for homologous recombination (HR) in yeast. Rad52 helps assemble
Rad51-ssDNA nucleoprotein filaments that catalyze DNA strand exchange, and it mediates …

Bloom helicase (BLM) and its orthologs are essential for the maintenance of genome
integrity. BLM defects represent the underlying cause of Bloom Syndrome, a rare genetic …

Homologous recombination is essential for DNA repair, replication and the exchange of
genetic material between parental chromosomes during meiosis. The stages of …

Homologous recombination during meiosis is crucial for the DNA double-strand breaks
(DSBs) repair that promotes the balanced segregation of homologous chromosomes and …

Helicases are in the spotlight of DNA metabolism and are critical for DNA repair in all
domains of life. At their biochemical core, they bind and hydrolyze ATP, converting this …