Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …

Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We …

Abstract Background: Elevated lipoprotein (a)(Lp [a]) is associated with aortic stenosis (AS).
Oxidized phospholipids (OxPL) are key mediators of calcification in valvular cells and are …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Although aortic stenosis is a common condition associated with major morbidity, mortality,
and health economic costs, there are currently no medical interventions capable of delaying …

Calcific aortic valve disease (CAVD) encompasses the range of disease from initial
alterations in the cell biology of the leaflets to end-stage calcification resulting in left …

Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

Objectives: The purpose of this study was to determine whether elevated lipoprotein (a)
levels and corresponding LPA risk genotypes (rs10455872, rs3798220, kringle IV type 2 …

Objectives. The aim of this study was to determine the prevalence of aortic sclerosis and
stenosis in the elderly and to identify clinical factors associated with degenerative aortic …