Vancomycin is the most frequently used antibiotic, accounting for up to 35% of hospitalized
patients with infection, because of its optimal bactericidal effectiveness and relatively low …

MRSA is a major cause of SSTIs. Several novel therapies covering MRSA were FDA-
approved for SSTIs. However, the current IDSA guidelines for MRSA infection and SSTIs as …

Drug-induced nephrotoxicity accounts for up to 60% of cases of acute kidney injury (AKI) in
hospitalized patients and is associated with increased morbidity and mortality in both adults …

Vancomycin, is widely used against methicillin-resistant bacterial infections. However,
Vancomycin accumulation causes nephrotoxicity which leads to an impairment in the …

Introduction Vancomycin, a commonly prescribed antibiotic particularly in the setting of multi-
drug resistant infections, is limited by its nephrotoxicity. Despite its common occurrence …

Immunocompromised individuals are at increased risk for opportunistic infections including
pneumonia. Opportunistic pneumonia has long been known to be a leading cause of …

Background: several blood-based biomarkers have been proposed for predicting
vancomycin-associated kidney injury (VIKI). However, no systematic analysis has compared …

Acute kidney injury (AKI) is a common syndrome in hospitalized patients and is associated
with increased morbidity and mortality. The focus of AKI care requires a shift away from …

Vancomycin (VCM)-induced nephrotoxicity impedes its treatment applications. Thus, it is
important to clarify the relevant mechanism. This study investigated phosphoprotein …

Understanding chronic kidney disease (CKD) through the lens of evolutionary biology
highlights the mismatch between our Paleolithic-optimized genes and modern diets, which …