Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by
liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly …

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

The hormone melatonin has many properties, including antioxidant, anti‐inflammatory, and
immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several …

Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic
nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the …

The pineal gland hormone melatonin continues to be of considerable interest to biomedical
researchers. Of particular interest is the pattern of secretion of melatonin in relation to sleep …

Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract.
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …

There continues to be considerable interest in the physiological role (s) of the hormone
melatonin and its potential as a drug more than 60 years after its discovery. While there is an …

Background and Aims Nonalcoholic fatty liver disease (NAFLD) is simple steatosis but can
develop into nonalcoholic steatohepatitis (NASH), characterized by liver inflammation …

Abstract Background 5-Fluorouracil (5-FU) has been established as the first-line
chemotherapy for advanced colorectal cancer (CRC); however, acquired chemoresistance …

Cholangiocytes, epithelial cells that line the biliary epithelium, are the primary target cells for
cholangiopathies including primary sclerosing cholangitis and primary biliary cholangitis …