Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …
[HTML][HTML] TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer's disease
Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
NA Schmacke, F O'Duill, MM Gaidt, I Szymanska… - Immunity, 2022 - cell.com
The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …
context of sterile inflammatory conditions. NLRP3 activity is governed by two independent …
[HTML][HTML] NLRP3 inflammasome activation in cancer: a double-edged sword
S Hamarsheh, R Zeiser - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is involved in tumor development and progression as well as antitumor
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …
Interleukin-1 beta as a target for atherosclerosis therapy: biological basis of CANTOS and beyond
P Libby - Journal of the American College of Cardiology, 2017 - jacc.org
Inflammatory pathways drive atherogenesis and link conventional risk factors to
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease
X Han, S Sun, Y Sun, Q Song, J Zhu, N Song, M Chen… - Autophagy, 2019 - Taylor & Francis
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …
periphery predisposes individuals to the development of neurodegenerative disorders …
NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma
Abstract The NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is
an immunological sensor that detects a wide range of microbial-and host-derived signals …
an immunological sensor that detects a wide range of microbial-and host-derived signals …
[HTML][HTML] Mitochondrial damage-associated molecular patterns: from inflammatory signaling to human diseases
S Grazioli, J Pugin - Frontiers in immunology, 2018 - frontiersin.org
Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …
[HTML][HTML] The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target
There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …
Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR‐223/NLRP3 axis
Y Zhang, X Liu, X Bai, Y Lin, Z Li, J Fu… - Journal of pineal …, 2018 - Wiley Online Library
Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin
is reported to possess substantial anti‐inflammatory properties, which has proven to be …
is reported to possess substantial anti‐inflammatory properties, which has proven to be …