Gamma sterilization of pharmaceuticals—a review of the irradiation of excipients, active pharmaceutical ingredients, and final drug product formulations

F Hasanain, K Guenther, WM Mullett… - PDA journal of …, 2014 - journal.pda.org
Sterilization by gamma irradiation has shown a strong applicability for a wide range of
pharmaceutical products. Due to the requirement for terminal sterilization where possible in …

Pharmaceuticals and related drugs

RK Gilpin, CS Gilpin - Analytical chemistry, 2007 - ACS Publications
The current article surveys pharmaceutical analysis and related methodology that has
appeared in the literature since the last review in this series was published in Analytical …

The effects of gamma irradiation on diclofenac sodium, liposome and niosome ingredients for rheumatoid arthritis

A Özer, S Turker, S Colak, M Korkmaz… - … Medicine and Applied …, 2013 - akjournals.com
The use of gamma rays for the sterilization of pharmaceutical raw materials and dosage
forms is an alternative method for sterilization. However, one of the major problems of the …

Radiosterilization of fluoroquinolones and cephalosporins: Assessment of radiation damage on antibiotics by changes in optical property and colorimetric parameters

B Singh, DV Parwate, SK Shukla - AAPS PharmSciTech, 2009 - Springer
A most common problem encountered in radiosterilization of solid drugs is discoloration or
yellowing. By pharmacopoeia method, discoloration can be assessed by measuring …

Gamma-irradiated liposome/niosome and lipogelosome/niogelosome formulations for the treatment of rheumatoid arthritis

S Turker, A Yekta Özer, E Kiliç, M Özalp… - … Medicine and Applied …, 2013 - akjournals.com
Abstract Treatment of rheumatoid arthritis by intraarticular administration of anti-inflammatory
drugs encapsulated in drug delivery systems, such as liposomes/niosomes and …

Ionizing radiation and its effects on pharmaceuticals

ET Sarcan, AY Ozer - Journal of Radioanalytical and Nuclear Chemistry, 2020 - Springer
Radiation is used for different purposes such as sterilization, imaging, analysis and security.
Sterilization, one of the the using area of radiation, is important issue for industries. The …

Oxidation of sulfamethoxazole by UVA radiation and modified Fenton reagent: toxicity and biodegradability of by-products

D Marciocha, J Kalka, J Turek-Szytow… - Water Science and …, 2009 - iwaponline.com
Improvement of sulfamethoxazole (4-amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide—
SMX) biodegradability using a modified Fenton's reaction has been studied. The …

EPR investigation of damage centers formed in some drug powders irradiated with gamma rays

K Sütçü - Journal of Molecular Structure, 2018 - Elsevier
The radiation damage centers in levetiracetam, progesterone, ethosuximide, and
propranolol hydrochloride were investigated by EPR spectroscopy at 295 K. The …

Influence of e-beam irradiation on sulfamethoxazole in solid state

M Ogrodowczyk, B Marciniec, M Hofman… - Analytical …, 2011 - jstage.jst.go.jp
Sulfamethoxazole, SMX (4-amino-N-(5-methyl-3-isoxazolyl)-benzenesulfonamide), belongs
to bacteriostatic drugs and is used, mainly together with trimetoprim, for the treatment of …

THE ROLE OF PHARMACEUTICAL ANALYSIS IN ENSURING THE SAFETY OF DRUG RADIATION STERILIZATION.

A KACZMAREK, M OGRODOWCZYK… - Acta Poloniae …, 2023 - search.ebscohost.com
Radiation sterilization is a widely used method for ensuring the sterility of medical and
pharmaceutical products. The process involves exposing the products to ionizing radiation …