Fundamental aspects of protein− protein association kinetics
The structure of a protein complex together with information about its affinity and other
thermodynamic characteristics provide a “frozen” view of the complex. This picture ignores …
thermodynamic characteristics provide a “frozen” view of the complex. This picture ignores …
Insights into cytokine–receptor interactions from cytokine engineering
Cytokines exert a vast array of immunoregulatory actions critical to human biology and
disease. However, the desired immunotherapeutic effects of native cytokines are often …
disease. However, the desired immunotherapeutic effects of native cytokines are often …
Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system
SL LaPorte, ZS Juo, J Vaclavikova, LA Colf, X Qi… - Cell, 2008 - cell.com
Summary Interleukin-4 and Interleukin-13 are cytokines critical to the development of T cell-
mediated humoral immune responses, which are associated with allergy and asthma, and …
mediated humoral immune responses, which are associated with allergy and asthma, and …
[HTML][HTML] Promiscuity and specificity in BMP receptor activation
TD Mueller, J Nickel - FEBS letters, 2012 - Elsevier
Bone Morphogenetic Proteins (BMPs), together with Transforming Growth Factor (TGF)-β
and Activins/Inhibins constitute the TGF-β superfamily of ligands. This superfamily is formed …
and Activins/Inhibins constitute the TGF-β superfamily of ligands. This superfamily is formed …
Predicting protein flexibility with AlphaFold
AlphaFold2 has revolutionized protein structure prediction from amino‐acid sequence. In
addition to protein structures, high‐resolution dynamics information about various protein …
addition to protein structures, high‐resolution dynamics information about various protein …
Evolution of in silico strategies for protein-protein interaction drug discovery
SJY Macalino, S Basith, NAB Clavio, H Chang, S Kang… - Molecules, 2018 - mdpi.com
The advent of advanced molecular modeling software, big data analytics, and high-speed
processing units has led to the exponential evolution of modern drug discovery and better …
processing units has led to the exponential evolution of modern drug discovery and better …
Interleukin-4 as a therapeutic target
Abstract Interleukin-4 (IL-4) is a pleiotropic cytokine mainly known for its role in type 2
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …
immunity. Therapies antagonizing or blocking IL-4 activity have been developed to …
The molecular architecture of protein–protein binding sites
D Reichmann, O Rahat, M Cohen, H Neuvirth… - Current opinion in …, 2007 - Elsevier
The formation of specific protein interactions plays a crucial role in most, if not all, biological
processes, including signal transduction, cell regulation, the immune response and others …
processes, including signal transduction, cell regulation, the immune response and others …
Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box
Abstract Studies on Interlukin-4 (IL-4) disclosed great deal of information about its various
physiological and pathological roles. All these roles depend upon its interaction and …
physiological and pathological roles. All these roles depend upon its interaction and …
Post-translational control of protein function by disulfide bond cleavage
Protein action in nature is largely controlled by the level of expression and by post-
translational modifications. Post-translational modifications result in a proteome that is at …
translational modifications. Post-translational modifications result in a proteome that is at …