Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials

TS Skinner-Adams, CM Stack, KR Trenholme… - Trends in Biochemical …, 2010 - cell.com
The neutral aminopeptidases M1 alanyl aminopeptidase (PfM1AAP) and M17 leucine
aminopeptidase (PfM17LAP) of the human malaria parasite Plasmodium falciparum are …

[HTML][HTML] Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes

A Rawat, M Roy, A Jyoti, S Kaushik, K Verma… - Microbiological …, 2021 - Elsevier
Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …

Falcipains, Plasmodium falciparum cysteine proteases as key drug targets against malaria

C Teixeira, J RB Gomes… - Current Medicinal …, 2011 - ingentaconnect.com
There is a high demand for new drugs against malaria, which takes millions of lives
annually. The abuse of classical antimalarials from the late 1940's to the early 1980's has …

Falcipains: biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials

J Patra, D Rana, S Arora, M Pal, N Mahindroo - European Journal of …, 2023 - Elsevier
Malaria is a tropical disease with significant morbidity and mortality burden caused by
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …

Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges

KK Roy - International Journal of Antimicrobial Agents, 2017 - Elsevier
Malaria is an infectious disease causing vast mortality and morbidity worldwide. Although
antimalarial drugs are effective in several parts of the world, there is a serious threat to …

Antimalarial activity of flavonoid compound isolated from leaves of Artocarpus altilis

AR Hidayati, A Widyawaruyanti, H Ilmi… - Pharmacognosy …, 2020 - phcogj.com
Introduction: Artocarpus altilis leaves extract has previously been reported as a potential
antimalarial drug. Inhibition concentration (IC 50) against P. falciparum and effective dose …

Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates

A Uddin, S Gupta, R Shoaib, B Aneja, I Irfan… - European Journal of …, 2024 - Elsevier
The persistence of drug resistance poses a significant obstacle to the advancement of
efficacious malaria treatments. The remarkable efficacy displayed by 1, 2, 3-triazole-based …

Identification and structure–activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease

A Uddin, V Singh, I Irfan, T Mohammad, RS Hada… - Bioorganic …, 2020 - Elsevier
In an effort to develop a potent anti-malarial agent against Plasmodium falciparum, a
structure-guided virtual screening using an in-house library comprising 652 compounds was …

Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery

BD Bekono, F Ntie-Kang, LC Owono Owono… - Current Drug …, 2018 - ingentaconnect.com
Background: The Plasmodium falciparum cysteine proteases, also known as falcipains, are
involved in different erythrocytic cycle processes of the malaria parasite, eg hydrolysis of …

Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress

GR Iyer, S Singh, I Kaur, S Agarwal, MA Siddiqui… - Journal of Biological …, 2018 - ASBMB
The human malaria parasite Plasmodium falciparum proliferates in red blood cells following
repeated cycles of invasion, multiplication, and egress. P. falciparum serine repeat antigen 5 …