Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
TS Skinner-Adams, CM Stack, KR Trenholme… - Trends in Biochemical …, 2010 - cell.com
The neutral aminopeptidases M1 alanyl aminopeptidase (PfM1AAP) and M17 leucine
aminopeptidase (PfM17LAP) of the human malaria parasite Plasmodium falciparum are …
aminopeptidase (PfM17LAP) of the human malaria parasite Plasmodium falciparum are …
[HTML][HTML] Cysteine proteases: Battling pathogenic parasitic protozoans with omnipresent enzymes
Millions of people worldwide lie at the risk of parasitic protozoic infections that kill over a
million people each year. The rising inefficacy of conventional therapeutics to combat these …
million people each year. The rising inefficacy of conventional therapeutics to combat these …
Falcipains, Plasmodium falciparum cysteine proteases as key drug targets against malaria
C Teixeira, J RB Gomes… - Current Medicinal …, 2011 - ingentaconnect.com
There is a high demand for new drugs against malaria, which takes millions of lives
annually. The abuse of classical antimalarials from the late 1940's to the early 1980's has …
annually. The abuse of classical antimalarials from the late 1940's to the early 1980's has …
Falcipains: biochemistry, target validation and structure-activity relationship studies of inhibitors as antimalarials
J Patra, D Rana, S Arora, M Pal, N Mahindroo - European Journal of …, 2023 - Elsevier
Malaria is a tropical disease with significant morbidity and mortality burden caused by
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …
Plasmodium species in Africa, the Middle East, Asia, and South America. Pathogenic …
Targeting the active sites of malarial proteases for antimalarial drug discovery: approaches, progress and challenges
KK Roy - International Journal of Antimicrobial Agents, 2017 - Elsevier
Malaria is an infectious disease causing vast mortality and morbidity worldwide. Although
antimalarial drugs are effective in several parts of the world, there is a serious threat to …
antimalarial drugs are effective in several parts of the world, there is a serious threat to …
Antimalarial activity of flavonoid compound isolated from leaves of Artocarpus altilis
Introduction: Artocarpus altilis leaves extract has previously been reported as a potential
antimalarial drug. Inhibition concentration (IC 50) against P. falciparum and effective dose …
antimalarial drug. Inhibition concentration (IC 50) against P. falciparum and effective dose …
Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates
The persistence of drug resistance poses a significant obstacle to the advancement of
efficacious malaria treatments. The remarkable efficacy displayed by 1, 2, 3-triazole-based …
efficacious malaria treatments. The remarkable efficacy displayed by 1, 2, 3-triazole-based …
Identification and structure–activity relationship (SAR) studies of carvacrol derivatives as potential anti-malarial against Plasmodium falciparum falcipain-2 protease
In an effort to develop a potent anti-malarial agent against Plasmodium falciparum, a
structure-guided virtual screening using an in-house library comprising 652 compounds was …
structure-guided virtual screening using an in-house library comprising 652 compounds was …
Targeting cysteine proteases from Plasmodium falciparum: a general overview, rational drug design and computational approaches for drug discovery
BD Bekono, F Ntie-Kang, LC Owono Owono… - Current Drug …, 2018 - ingentaconnect.com
Background: The Plasmodium falciparum cysteine proteases, also known as falcipains, are
involved in different erythrocytic cycle processes of the malaria parasite, eg hydrolysis of …
involved in different erythrocytic cycle processes of the malaria parasite, eg hydrolysis of …
Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress
The human malaria parasite Plasmodium falciparum proliferates in red blood cells following
repeated cycles of invasion, multiplication, and egress. P. falciparum serine repeat antigen 5 …
repeated cycles of invasion, multiplication, and egress. P. falciparum serine repeat antigen 5 …