Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

Tuberculosis (TB) still continues to be a major killer disease worldwide. Unlike other bacteria
Mycobacterium tuberculosis (Mtb) has the ability to become dormant within the host and to …

Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …

The rise of antibiotic resistance necessitates the search for new platforms for drug
development. Prodrugs are common tools for overcoming drawbacks typically associated …

PE/PPE family proteins, named after their conserved PE (Pro-Glu) and PPE (Pro-Pro-Glu)
domains of N-terminal, are most intriguing aspects of pathologic mycobacterial genome. The …

Tuberculosis is still a cause of major concern, partly due to the emergence of multidrug-
resistant strains. New drugs are therefore needed. Vancomycin can target mycobacteria with …

Targeting M. tuberculosis (Mtb) in latent form of infection is a major obstacle and big
challenge in tuberculosis (TB) eradication by current chemotherapy. A better understanding …

We have investigated the role of Rv3097c-encoded lipase (LipY) on the virulence of
Mycobacterium tuberculosis. It has been shown that the overexpression of LipY in strain …

Tuberculosis (TB) is a global threat with a large burden across the continents in terms of
mortality, morbidity, and financial losses. The disease has evolved into multi-drug-resistant …