The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

De novo and acquired resistance, which are largely attributed to genetic alterations, are
barriers to effective anti-epidermal-growth-factor-receptor (EGFR) therapy. To generate …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …

Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

MicroRNAs (miRNAs) are short, noncoding RNAs that posttranscriptionally regulate gene
expression. In the past decade, studies on miRNAs in ovaries have revealed the key roles of …

The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Epithelial-mesenchymal transition (EMT) is a major contributor to metastatic progression and
is prominently regulated by TGF-β signalling. Both EMT and TGF-β pathway components are …