The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

EMT-associated heterogeneity in circulating tumor cells: sticky friends on the road to metastasis

A Genna, AM Vanwynsberghe, AV Villard, C Pottier… - Cancers, 2020 - mdpi.com
Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Electrochemical/visual microfluidic detection with a covalent organic framework supported platinum nanozyme-based device for early diagnosis of pheochromocytoma

X Liu, F Wang, Y Meng, L Zhao, W Shi, X Wang… - Biosensors and …, 2022 - Elsevier
The development of smart, portable, and sensitive devices for the monitoring of circulating
tumor cells (CTCs) is essential to diagnose several diseases, including pheochromocytoma …

Gene expression in circulating tumor cells reveals a dynamic role of EMT and PD-L1 during osimertinib treatment in NSCLC patients

A Ntzifa, A Strati, G Kallergi, A Kotsakis… - Scientific Reports, 2021 - nature.com
Liquid biopsy is a tool to unveil resistance mechanisms in NSCLC. We studied changes in
gene expression in CTC-enriched fractions of EGFR-mutant NSCLC patients under …

First evidence of AXL expression on circulating tumor cells in metastatic breast cancer patients: A proof‐of‐concept study

T Bardol, Z Eslami‐S, D Masmoudi… - Cancer …, 2024 - Wiley Online Library
Background For several years, the AXL tyrosine kinase receptor, a member of the Tyro3‐Axl‐
Mer (TAM) family, has been considered a new strategic target in oncology. AXL …

Axl contributes to efficient migration and invasion of melanoma cells

H Shao, D Teramae, A Wells - PloS one, 2023 - journals.plos.org
Axl, a member of the TAM receptor family has been broadly suggested to play a key role in
tumor metastasis. However, the function of Axl in the invasion and metastasis of melanoma …

Dual-targeting nanoprobe for early diagnosis of pheochromocytoma though coinstantaneous identification of circulating tumor cells

X Liu, X Zhang, J Tang, Y Meng, L Zhao, W Shi… - Analytical …, 2021 - ACS Publications
Circulating tumor cells (CTCs) play a pivotal role in the early diagnosis of
pheochromocytoma (PCC). Herein, we fabricated a new dual-targeting nanoprobe for …

Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies

D Jahagirdar, P Bangde, R Jain… - Biotechnology …, 2021 - Wiley Online Library
Background Understanding the pathophysiology of degenerative diseases pertaining to
nervous system, ocular region, bone/cartilage, and muscle are still being comprehended …

Novel Circulating Tumour Cell‐Related Risk Model Indicates Prognosis and Immune Infiltration in Lung Adenocarcinoma

L Liang, Y Liu, S Jiang, J Huang, H He… - Journal of …, 2022 - Wiley Online Library
Background. Lung adenocarcinoma (LUAD) is the most common histological subtype of
lung cancer (LC) and one of the leading causes of cancer‐related death worldwide. LUAD …

Advances in the biology, detection techniques, and clinical applications of circulating tumor cells

S Wu, S Zhao, D Cui, J Xie - Journal of Oncology, 2022 - Wiley Online Library
Circulating tumor cells (CTCs) play a crucial role in tumor recurrence and metastasis, and
their early detection has shown remarkable benefits in clinical theranostics. However, CTCs …