Microbial dysbiosis in the gut drives systemic autoimmune diseases

WK Mousa, F Chehadeh, S Husband - Frontiers in immunology, 2022 - frontiersin.org
Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

Gut microbiome, intestinal permeability, and tissue bacteria in metabolic disease: perpetrators or bystanders?

RM Chakaroun, L Massier, P Kovacs - Nutrients, 2020 - mdpi.com
The emerging evidence on the interconnectedness between the gut microbiome and host
metabolism has led to a paradigm shift in the study of metabolic diseases such as obesity …

Gut microbiota, obesity and diabetes

E Patterson, PM Ryan, JF Cryan… - Postgraduate …, 2016 - academic.oup.com
The central role of the intestinal microbiota in the progression and, equally, prevention of
metabolic dysfunction is becoming abundantly apparent. The symbiotic relationship …

Probiotics and the gut immune system: indirect regulation

G La Fata, P Weber, MH Mohajeri - Probiotics and antimicrobial proteins, 2018 - Springer
The gastrointestinal tract (GIT) represents the largest interface between the human organism
and the external environment. In the lumen and upper part of the mucus layer, this organ …

[HTML][HTML] The role of gut microbiota in the development of obesity and diabetes

OA Baothman, MA Zamzami, I Taher… - Lipids in health and …, 2016 - Springer
Obesity and its associated complications like type 2 diabetes (T2D) are reaching epidemic
stages. Increased food intake and lack of exercise are two main contributing factors. Recent …

Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex

L Rizzetto, F Fava, KM Tuohy, C Selmi - Journal of autoimmunity, 2018 - Elsevier
Unresolved low grade systemic inflammation represents the underlying pathological
mechanism driving immune and metabolic pathways involved in autoimmune diseases …

The role of the intestinal microbiota in type 1 diabetes mellitus

M Knip, H Siljander - Nature Reviews Endocrinology, 2016 - nature.com
Type 1 diabetes mellitus (T1DM) is a chronic immune-mediated disease with a subclinical
prodromal period, characterized by selective loss of insulin-producing-β cells in the …

The role of gut microbiota in immune homeostasis and autoimmunity

HJ Wu, E Wu - Gut microbes, 2012 - Taylor & Francis
Keeping a delicate balance in the immune system by eliminating invading pathogens, while
still maintaining self-tolerance to avoid autoimmunity, is critical for the body's health. The gut …

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes

CT Brown, AG Davis-Richardson, A Giongo, KA Gano… - PloS one, 2011 - journals.plos.org
Recent studies have suggested a bacterial role in the development of autoimmune disorders
including type 1 diabetes (T1D). Over 30 billion nucleotide bases of Illumina shotgun …

Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology

H Hardy, J Harris, E Lyon, J Beal, AD Foey - Nutrients, 2013 - mdpi.com
Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in
combination with prebiotics,(indigestible dietary fibre/carbohydrate), also confer a health …