miR-218: A stress-responsive epigenetic modifier
G Schell, B Roy, K Prall, Y Dwivedi - Non-coding RNA, 2022 - mdpi.com
Understanding the epigenetic role of microRNAs (miRNAs) has been a critical development
in the field of neuropsychiatry and in understanding their underlying pathophysiology …
in the field of neuropsychiatry and in understanding their underlying pathophysiology …
miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes …
S Pulcrano, R De Gregorio, C De Sanctis… - Journal of …, 2023 - Soc Neuroscience
In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic
plasticity at a higher level by acting as an additional mechanism of translational regulation …
plasticity at a higher level by acting as an additional mechanism of translational regulation …
enrichMiR predicts functionally relevant microRNAs based on target collections
M Soutschek, T Germade, PL Germain… - Nucleic Acids …, 2022 - academic.oup.com
MicroRNAs (miRNAs) are small non-coding RNAs that are among the main post-
transcriptional regulators of gene expression. A number of data collections and prediction …
transcriptional regulators of gene expression. A number of data collections and prediction …
miR-329–and miR-495–mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons
MO Inouye, D Colameo, I Ammann… - Life Science …, 2022 - life-science-alliance.org
Homeostatic synaptic depression (HSD) in excitatory neurons is a cell-autonomous
mechanism which protects excitatory neurons from over-excitation as a consequence of …
mechanism which protects excitatory neurons from over-excitation as a consequence of …
Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress
The underlying biological mechanisms that contribute to the heterogeneity of major
depressive disorder (MDD) presentation remain poorly understood, highlighting the need for …
depressive disorder (MDD) presentation remain poorly understood, highlighting the need for …
GOAT: efficient and robust identification of gene set enrichment
F Koopmans - Communications Biology, 2024 - nature.com
Gene set enrichment analysis is foundational to the interpretation of high throughput biology.
Identifying enriched Gene Ontology (GO) terms or disease-associated gene sets within a list …
Identifying enriched Gene Ontology (GO) terms or disease-associated gene sets within a list …
Synaptic tagging: homeostatic plasticity goes Hebbian
D Colameo, G Schratt - The EMBO Journal, 2022 - embopress.org
Distinct plasticity mechanisms enable neurons to effectively process information also when
facing global perturbations in network activity. In this issue of The EMBO Journal, Dubes et …
facing global perturbations in network activity. In this issue of The EMBO Journal, Dubes et …
A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons
D Kelly, S Bicker, J Winterer, P Nanda, PL Germain… - bioRxiv, 2024 - biorxiv.org
Circular RNAs (circRNAs) are an expanding class of largely unexplored RNAs which are
prominently enriched in the mammalian brain. Here, we systematically interrogated their role …
prominently enriched in the mammalian brain. Here, we systematically interrogated their role …
Screening and Characterization of Functional circRNAs in Neuronal Cultures
D Kelly, G Schratt - Circular RNAs, 2024 - Springer
This chapter describes a methodology for the screening and characterization of functional
circRNAs, particularly in the context of neural circuit development. Taking advantage of a …
circRNAs, particularly in the context of neural circuit development. Taking advantage of a …
microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity
D Colameo, SM Maley, W ElGrawani, C Gilardi… - bioRxiv, 2023 - biorxiv.org
Homeostatic synaptic plasticity (HSP) is a fundamental neuronal mechanism that allows
networks to compensate for prolonged changes in activity by adjusting synaptic strength …
networks to compensate for prolonged changes in activity by adjusting synaptic strength …