miR-218: A stress-responsive epigenetic modifier

G Schell, B Roy, K Prall, Y Dwivedi - Non-coding RNA, 2022 - mdpi.com
Understanding the epigenetic role of microRNAs (miRNAs) has been a critical development
in the field of neuropsychiatry and in understanding their underlying pathophysiology …

miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes …

S Pulcrano, R De Gregorio, C De Sanctis… - Journal of …, 2023 - Soc Neuroscience
In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic
plasticity at a higher level by acting as an additional mechanism of translational regulation …

enrichMiR predicts functionally relevant microRNAs based on target collections

M Soutschek, T Germade, PL Germain… - Nucleic Acids …, 2022 - academic.oup.com
MicroRNAs (miRNAs) are small non-coding RNAs that are among the main post-
transcriptional regulators of gene expression. A number of data collections and prediction …

miR-329–and miR-495–mediated Prr7 down-regulation is required for homeostatic synaptic depression in rat hippocampal neurons

MO Inouye, D Colameo, I Ammann… - Life Science …, 2022 - life-science-alliance.org
Homeostatic synaptic depression (HSD) in excitatory neurons is a cell-autonomous
mechanism which protects excitatory neurons from over-excitation as a consequence of …

Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress

X Zhang, MA Eladawi, WG Ryan, X Fan… - PNAS …, 2023 - academic.oup.com
The underlying biological mechanisms that contribute to the heterogeneity of major
depressive disorder (MDD) presentation remain poorly understood, highlighting the need for …

GOAT: efficient and robust identification of gene set enrichment

F Koopmans - Communications Biology, 2024 - nature.com
Gene set enrichment analysis is foundational to the interpretation of high throughput biology.
Identifying enriched Gene Ontology (GO) terms or disease-associated gene sets within a list …

Synaptic tagging: homeostatic plasticity goes Hebbian

D Colameo, G Schratt - The EMBO Journal, 2022 - embopress.org
Distinct plasticity mechanisms enable neurons to effectively process information also when
facing global perturbations in network activity. In this issue of The EMBO Journal, Dubes et …

A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons

D Kelly, S Bicker, J Winterer, P Nanda, PL Germain… - bioRxiv, 2024 - biorxiv.org
Circular RNAs (circRNAs) are an expanding class of largely unexplored RNAs which are
prominently enriched in the mammalian brain. Here, we systematically interrogated their role …

Screening and Characterization of Functional circRNAs in Neuronal Cultures

D Kelly, G Schratt - Circular RNAs, 2024 - Springer
This chapter describes a methodology for the screening and characterization of functional
circRNAs, particularly in the context of neural circuit development. Taking advantage of a …

microRNA-218-5p Coordinates Scaling of Excitatory and Inhibitory Synapses during Homeostatic Synaptic Plasticity

D Colameo, SM Maley, W ElGrawani, C Gilardi… - bioRxiv, 2023 - biorxiv.org
Homeostatic synaptic plasticity (HSP) is a fundamental neuronal mechanism that allows
networks to compensate for prolonged changes in activity by adjusting synaptic strength …