Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …

The MobiDB database (URL: https://mobidb. org/) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …

The MobiDB (URL: mobidb. bio. unipd. it) database of protein disorder and mobility
annotations has been significantly updated and upgraded since its last major renewal in …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

Owing to their outstanding performances in molecular recognition, antibodies are
extensively used in research and applications in molecular biology, biotechnology and …

High-throughput sequencing methods are generating enormous amounts of genomic data,
giving unprecedented insights into human genetic variation and its relation to disease. An …

The hydrophobic effect is the main driving force in protein folding. One can estimate the
relative strength of this hydrophobic effect for each amino acid by mining a large set of …

It is becoming increasingly recognised that disordered proteins may be fuzzy, in that they
can exhibit a wide variety of binding modes. In addition to the well-known process of folding …

Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …