The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Congenital hypogonadotropic hypogonadism (CHH) is a clinically and genetically
heterogeneous congenital disease. Symptoms cover a wide spectrum from mild forms to …

The nitric oxide (NO) signaling pathway in hypothalamic neurons plays a key role in the
regulation of the secretion of gonadotropin-releasing hormone (GnRH), which is crucial for …

Congenital hypogonadotropic hypogonadism (CHH) is a rare endocrine disorder that results
in reproductive hormone deficiency and reduced potential for fertility in adult life. Discoveries …

Hypogonadotropic hypogonadism, which may be normosmic (nHH) or anosmic/hyposmic,
known as Kallmann syndrome (KS), is due to gonadotropin-releasing hormone deficiency …

Sex development is a very complex biological event that requires the concerted
collaboration of a large network of genes in a spatial and temporal correct fashion. In the …

Background: Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disease
caused by Gonadotropin-Releasing Hormone (GnRH) deficiency. So far a limited number of …

Context Pubertal delay can be the clinical presentation of both idiopathic hypogonadotropic
hypogonadism (IHH) and self-limited delayed puberty (SLDP). Distinction between these …

Distinguishing between self limited delayed puberty (SLDP) and congenital
hypogonadotropic hypogonadism (CHH) may be tricky as they share clinical and …

Hypopituitarism, or the failure to secrete hormones produced by the anterior pituitary
(adenohypophysis) and/or to release hormones from the posterior pituitary …