Healthy kidneys maintain fluid and electrolyte homoeostasis by adjusting urine volume and
composition according to physiological needs. The final urine composition is determined in …

Alterations in water homeostasis can disturb cell size and function. Although most cells can
internally regulate cell volume in response to osmolar stress, neurons are particularly at risk …

In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …

The water channel aquaporin-2 (AQP2), expressed in the kidney collecting ducts, plays a
pivotal role in maintaining body water balance. The channel is regulated by the peptide …

Hypernatremia is defined as a serum sodium level above 145 mmol/L. It is a frequently
encountered electrolyte disturbance in the hospital setting, with an unappreciated high …

Abstract Background Aquaporins (AQPs) are a family of proteins that can act as water
channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body …

Diabetes insipidus (DI) is a hereditary or acquired condition which disrupts normal life of
persons with the condition; disruption is due to increased thirst and passing of large volumes …

Non‐technical summary Like most cells, those of the kidney release protein and RNA in
structures called exosomes. It is possible that the contents of exosomes released into the …

Lithium is the first line therapy of bipolar mood disorder. Lithium-induced nephrogenic
diabetes insipidus (Li-NDI) and lithium nephropathy (Li-NP, ie, renal insufficiency) are …

Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …