Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle
apparatus. Centrosomes themselves duplicate once per cell cycle, in a process that is …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

In normal human cells, centrosome loss induced by centrinone—a specific centrosome
duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown …

Centriole duplication occurs once per cell cycle in order to maintain control of centrosome
number and ensure genome integrity. Polo-like kinase 4 (Plk4) is a master regulator of …

As cells enter mitosis, the two centrosomes separate and grow dramatically, each forming a
nascent spindle pole that nucleates a radial array of microtubules. Centrosome growth (and …

Centrosomes are the main microtubule-organizing centre of animal cells and are important
for many critical cellular and developmental processes from cell polarization to cell division …