This review covers current developments in molecular-based studies of the structure and
function of carboxylesterases. To allay the confusion of the classic classification of …

Background: Carboxylesterases (CES) play a critical role in catalyzing hydrolysis of esters,
amides, carbamates and thioesters, as well as bioconverting prodrugs and soft drugs. The …

In silico drug target identification, which includes many distinct algorithms for finding disease
genes and proteins, is the first step in the drug discovery pipeline. When the 3D structures of …

Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis
remains a significant challenge due to complex physical environment. Human …

Carboxylesterases (CE) are members of the esterase family of enzymes, and as their name
suggests, they are responsible for the hydrolysis of carboxylesters into the corresponding …

Almost all therapeutic proteins are glycosylated, with the carbohydrate component playing a
long-established, substantial role in the safety and pharmacokinetic properties of this …

The purpose of this review is to examine uses of carboxylesterase activity in environmental
monitoring with a specific emphasis on pyrethroid insecticides. The chapter begins with an …

The human carboxylesterase 1 (CES1) gene encodes for the enzyme carboxylesterase 1, a
serine esterase governing both metabolic deactivation and activation of numerous …

Prodrug design is an important part of drug discovery. Prodrugs can offer many advantages
over parent drugs such as increased solubility, enhanced stability, improved bioavailability …

Mammalian carboxylesterase (CES or Ces) genes encode enzymes that participate in
xenobiotic, drug, and lipid metabolism in the body and are members of at least five gene …