Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells.
However, the effective use of anti-CD20 treatment now also reveals an important role for B …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …

Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …

Background: Strong genetic and epidemiological evidence points to a crucial role of the
immune system in the development of Alzheimer disease (AD). CD3+ T lymphocytes have …

T cells are considered pivotal in the pathology of multiple sclerosis (MS), but their function
and antigen specificity are unknown. To unravel the role of T cells in MS pathology, we …

Aging is associated with an increase in basal inflammation in the CNS and an overall
decline in cognitive function and poorer recovery following injury. Growing evidence …

Cerebral beta-amyloidosis, one of the pathological hallmarks of Alzheimer's disease (AD),
elicits a well-characterised, microglia-mediated local innate immune response. In contrast, it …