Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit
Objective: To revise the “Clinical Practice Guidelines for the Sustained Use of Sedatives and
Analgesics in the Critically Ill Adult” published in Critical Care Medicine in 2002. Methods …
Analgesics in the Critically Ill Adult” published in Critical Care Medicine in 2002. Methods …
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding
KN Iskander, MF Osuchowski… - Physiological …, 2013 - journals.physiology.org
Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …
substantial human morbidity resulting in hundreds of thousands of deaths each year …
Sepsis pathophysiology, chronic critical illness, and persistent inflammation-immunosuppression and catabolism syndrome
JC Mira, LF Gentile, BJ Mathias, PA Efron… - Critical care …, 2017 - journals.lww.com
Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
Objective: To provide an update to the “Surviving Sepsis Campaign Guidelines for
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …
Management of Severe Sepsis and Septic Shock,” last published in 2008. Design: A …
Fluid overload in patients with severe sepsis and septic shock treated with early goal-directed therapy is associated with increased acute need for fluid-related medical …
DJ Kelm, JT Perrin, R Cartin-Ceba, O Gajic, L Schenck… - Shock, 2015 - journals.lww.com
Early goal-directed therapy (EGDT) consists of early, aggressive fluid resuscitation and is
known to improve survival in sepsis. It is unknown how often EGDT leads to subsequent fluid …
known to improve survival in sepsis. It is unknown how often EGDT leads to subsequent fluid …
A targeted real-time early warning score (TREWScore) for septic shock
Sepsis is a leading cause of death in the United States, with mortality highest among
patients who develop septic shock. Early aggressive treatment decreases morbidity and …
patients who develop septic shock. Early aggressive treatment decreases morbidity and …
Nationwide trends of severe sepsis in the 21st century (2000–2007)
Background Severe sepsis is common and often fatal. The expanding armamentarium of
evidence-based therapies has improved the outcomes of persons with this disease …
evidence-based therapies has improved the outcomes of persons with this disease …
[HTML][HTML] Effect of performance improvement programs on compliance with sepsis bundles and mortality: a systematic review and meta-analysis of observational …
E Damiani, A Donati, G Serafini, L Rinaldi, E Adrario… - PloS one, 2015 - journals.plos.org
Background Several reports suggest that implementation of the Surviving Sepsis Campaign
(SSC) guidelines is associated with mortality reduction in sepsis. However, adherence to the …
(SSC) guidelines is associated with mortality reduction in sepsis. However, adherence to the …
[HTML][HTML] Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference
This paper reports on the consensus conference on the management of intra-abdominal
infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual …
infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual …
Delay within the 3-hour surviving sepsis campaign guideline on mortality for patients with severe sepsis and septic shock
Objectives: To specify when delays of specific 3-hour bundle Surviving Sepsis Campaign
guideline recommendations applied to severe sepsis or septic shock become harmful and …
guideline recommendations applied to severe sepsis or septic shock become harmful and …