Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

The collective of endocrine organs acting in homeostatic regulation—known as the
hypothalamic-pituitary-adrenal (HPA) axis—comprises an integration of the central nervous …

Atrial fibrillation (AF) is associated with significant morbidity and mortality. It is also a
progressive disease secondary to continuous structural remodelling of the atria due to AF …

Background and aim Considering the amount of novel knowledge generated in the last five
years, a team of experienced hypertensionlogists was assembled to furnish updated clinical …

Abstract Characterization of mice with cell-specific deletion or overexpression of the
mineralocorticoid receptor (MR) shed a new light on its role in health and disease …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Background—Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) gene therapy
improves mechanical function in heart failure and is under evaluation in a clinical trial. A …

With increasing life span as afforded by nutritional, technological, and therapeutic
advancements during the last century, cardiac diseases have moved to the top of morbidity …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …