Aldosterone as a mediator of cardiovascular damage
Besides the physiological regulation of water, sodium, and potassium homeostasis,
aldosterone modulates several physiological and pathological processes in the …
aldosterone modulates several physiological and pathological processes in the …
Emerging roles of the mineralocorticoid receptor in pathology: toward new paradigms in clinical pharmacology
F Jaisser, N Farman - Pharmacological reviews, 2016 - ASPET
The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …
Hypothalamic-pituitary-adrenal axis modulation of glucocorticoids in the cardiovascular system
NG Burford, NA Webster, D Cruz-Topete - International journal of …, 2017 - mdpi.com
The collective of endocrine organs acting in homeostatic regulation—known as the
hypothalamic-pituitary-adrenal (HPA) axis—comprises an integration of the central nervous …
hypothalamic-pituitary-adrenal (HPA) axis—comprises an integration of the central nervous …
Upstream therapies for management of atrial fibrillation: review of clinical evidence and implications for European Society of Cardiology guidelines. Part I: primary …
I Savelieva, N Kakouros, A Kourliouros, AJ Camm - Europace, 2011 - academic.oup.com
Atrial fibrillation (AF) is associated with significant morbidity and mortality. It is also a
progressive disease secondary to continuous structural remodelling of the atria due to AF …
progressive disease secondary to continuous structural remodelling of the atria due to AF …
[HTML][HTML] The 2020 Italian Society of Arterial Hypertension (SIIA) practical guidelines for the management of primary aldosteronism
GP Rossi, V Bisogni, AV Bacca, A Belfiore… - International Journal of …, 2020 - Elsevier
Background and aim Considering the amount of novel knowledge generated in the last five
years, a team of experienced hypertensionlogists was assembled to furnish updated clinical …
years, a team of experienced hypertensionlogists was assembled to furnish updated clinical …
Steroidal and novel non-steroidal mineralocorticoid receptor antagonists in heart failure and cardiorenal diseases: comparison at bench and bedside
P Kolkhof, F Jaisser, SY Kim, G Filippatos, C Nowack… - Heart failure, 2017 - Springer
Abstract Characterization of mice with cell-specific deletion or overexpression of the
mineralocorticoid receptor (MR) shed a new light on its role in health and disease …
mineralocorticoid receptor (MR) shed a new light on its role in health and disease …
RyR2 and calcium release in heart failure
JP Benitah, R Perrier, JJ Mercadier, L Pereira… - Frontiers in …, 2021 - frontiersin.org
Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …
SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure
AR Lyon, ML Bannister, T Collins… - Circulation …, 2011 - Am Heart Assoc
Background—Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) gene therapy
improves mechanical function in heart failure and is under evaluation in a clinical trial. A …
improves mechanical function in heart failure and is under evaluation in a clinical trial. A …
Arrhythmogenic implications of fibroblast-myocyte interactions
S Rohr - Circulation: Arrhythmia and Electrophysiology, 2012 - Am Heart Assoc
With increasing life span as afforded by nutritional, technological, and therapeutic
advancements during the last century, cardiac diseases have moved to the top of morbidity …
advancements during the last century, cardiac diseases have moved to the top of morbidity …
Role of aldosterone and mineralocorticoid receptor in cardiovascular aging
The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …
pressure, able to modulate renal sodium handling in response to its principal ligand …