Peptides fulfill a plethora of functions in plant growth, development, and stress responses.
They act as key components of cell-to-cell communication, interfere with signaling and …

Highlights•The human proteasome is the second largest drug target class.•Few prototypic
proteases are standard tools for the discovery of novel inhibitors.•Peptide protease inhibitors …

How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …

Bowman-Birk inhibitors (BBIs) are found primarily in seeds of legumes and in cereal grains.
These canonical inhibitors share a highly conserved nine-amino acids binding loop motif …

Nature‐derived cyclic peptides have proven to be a vast source of inspiration for advancing
modern pharmaceutical design and synthetic chemistry. The focus of this Review is …

Proteases usually cleave peptides, but under some conditions, they can ligate them. Seeds
of the common sunflower contain the 14-residue, backbone-macrocyclic peptide sunflower …

Introduction: Macrocyclic peptides are generally more resistant to proteolysis and often have
higher potency than linear peptides and so they are excellent leads in drug design. Their …

Covering 1965 to February 2024Plants are prolific peptide chemists and are known to make
thousands of different peptidic molecules. These peptides vary dramatically in their size …

Cyclic and branch cyclic peptides (cyclopeptides) represent a class of bioactive natural
products that include many antibiotics and anti-tumor compounds. Despite the recent …

Cyclic peptides present a robust platform for drug design, offering high specificity and
stability due to their conformationally constrained structures. In this study, we introduce an …