The intestinal milieu harbours the gut microbiota, consisting of a complex community of
bacteria, archaea, fungi, viruses and protozoans that bring to the host organism an …

Studies over several decades have documented the beneficial actions of n-3
polyunsaturated fatty acids (PUFAs), which are plentiful in fish oil, in different disease states …

Annotating the molecular basis of human disease remains an unsolved challenge, as 93%
of disease loci are non-coding and gene-regulatory annotations are highly incomplete …

It is widely recognized that the microorganisms inhabiting our gastrointestinal tract—the gut
microbiota—deeply affect the pathophysiology of the host. Gut microbiota composition is …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

In recent years, gut microbiota as an immune organ has gradually become the mainstream
of research. When the composition of the gut microbiota is changed significantly, this may …

Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six
widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological …

Atherosclerosis (AS) manifested by lipid accumulation, extracellular matrix protein
deposition, and calcification in the intima and media of the large to medium size arteries …

The liver is an essential multifunctional organ, which constantly communicates with nearly
all tissues. It has raised the concern that microgravity exposure can lead to liver dysfunction …

Objective: Genome-wide association studies identified novel loci in PLPP3 (phospholipid
phosphatase 3) that associate with coronary artery disease risk independently of traditional …