[HTML][HTML] GLP-1 receptor agonists in the treatment of type 2 diabetes–state-of-the-art

MA Nauck, DR Quast, J Wefers, JJ Meier - Molecular metabolism, 2021 - Elsevier
Background GLP-1 receptor agonists (GLP-1 RAs) with exenatide bid first approved to treat
type 2 diabetes in 2005 have been further developed to yield effective compounds …

The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)

DM Tanase, EM Gosav, CF Costea… - Journal of diabetes …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one
of the most global problematic metabolic diseases with rapidly increasing prevalence and …

Pharmacotherapy of type 2 diabetes: An update and future directions

A DeMarsilis, N Reddy, C Boutari, A Filippaios… - Metabolism, 2022 - Elsevier
Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

Sodium–glucose cotransporter type 2 inhibitors for the treatment of type 2 diabetes mellitus

AJ Scheen - Nature reviews endocrinology, 2020 - nature.com
The management of type 2 diabetes mellitus (T2DM) is becoming increasingly complex.
Sodium–glucose cotransporter type 2 inhibitors (SGLT2is) are the newest antidiabetic …

The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: a systematic review and meta …

C Li, J Luo, M Jiang, K Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
Aims: Glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2
inhibitors play a key role in the treatment of type 2 diabetes mellitus. This meta-analysis aims …

Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy

X Lu, Q Xie, X Pan, R Zhang, X Zhang… - … and Targeted Therapy, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive
loss of islet β cell insulin secretion usually occurring after the presence of insulin resistance …

Newer pharmacologic treatments in adults with type 2 diabetes: a systematic review and network meta-analysis for the American College of Physicians

T Drake, A Landsteiner, L Langsetmo… - Annals of internal …, 2024 - acpjournals.org
Background: Newer diabetes medications may have beneficial effects on mortality,
cardiovascular outcomes, and renal outcomes. Purpose: To evaluate the effectiveness …

Effects of GLP-1 receptor agonists and SGLT-2 inhibitors on cardiac structure and function: a narrative review of clinical evidence

A Natali, L Nesti, D Tricò, E Ferrannini - Cardiovascular Diabetology, 2021 - Springer
The impressive results of recent clinical trials with glucagon-like peptide-1 receptor agonists
(GLP-1Ra) and sodium glucose transporter 2 inhibitors (SGLT-2i) in terms of cardiovascular …

Efficacy of modern diabetes treatments DPP-4i, SGLT-2i, and GLP-1RA in white and Asian patients with diabetes: a systematic review and meta-analysis of …

S Gan, AY Dawed, LA Donnelly, ATN Nair… - Diabetes …, 2020 - Am Diabetes Assoc
BACKGROUND The pathophysiology of type 2 diabetes differs markedly by ethnicity.
PURPOSE A systematic review and meta-analysis was conducted to assess the impact of …

Comparative cardiovascular outcomes of SGLT2 inhibitors in type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials

Y Jiang, P Yang, L Fu, L Sun, W Shen… - Frontiers in …, 2022 - frontiersin.org
Background A network meta-analysis of randomized controlled trials (RCTs) was conducted
to explore the cardiovascular outcomes of all the kind and dosages of sodium-glucose …