G protein‐coupled receptors (GPCRs) play critical roles in the regulation of human
physiology in response to a wide array of different extracellular stimuli and thus represent …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …

Summary The D1-and D2-dopamine receptors (D1R and D2R), which signal through G s
and G i, respectively, represent the principal stimulatory and inhibitory dopamine receptors …

G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and
are important drug targets. Their diverse signaling pathways are driven by complex …

Dopamine receptors, including D1-and D2-like receptors, are important therapeutic targets
in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here …

Abstract Sphingosine-1-phosphate receptor 1 (S1PR1) is a master regulator of lymphocyte
egress from the lymph node and an established drug target for multiple sclerosis (MS) …

Histamine receptors play important roles in various pathophysiological conditions and are
effective targets for anti-allergy treatment, however the mechanism of receptor activation …

Obesity is a global epidemic that causes morbidity and impaired quality of life. The
melanocortin receptor 4 (MC4R) is at the crux of appetite, energy homeostasis, and body …

Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …