Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

Immunotherapy targeting the autoimmune process in type 1 diabetes (T1D) can delay the
loss of β-cells but needs to have minimal adverse effects to be an adjunct to insulin in the …

Autoimmune disorders (ADs) are multifactorial diseases involving, genetic, epigenetic, and
environmental factors characterized by an inappropriate immune response toward self …

Susceptibility to type 1 diabetes is associated strongly with human leucocyte antigen (HLA)
genes, implicating T cells in disease pathogenesis. In humans, CD8 T cells predominantly …

The remarkable plasticity of CD4+ T cells allows individuals to respond to environmental
stimuli in a context‐dependent manner. A balance of CD4+ T cell subsets is critical to mount …

Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis
still remain unknown. Most researchers allude to the possible autoimmune or immune …

Accumulating evidence indicates that metabolism reprogramming is critically important to T
cell differentiation, and manipulating metabolic pathways in T cells can shape their fate and …

We have previously reported the molecular signature of murine pathogenic TH17 cells that
induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that …

We have shown that bone marrow (BM)-derived mesenchymal stem cells (BM-MSCs) from
SLE patients exhibit senescent behavior and are involved in the pathogenesis of SLE. The …