Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-
zygotic transition,. However, the identity of transcription factors that underlie mammalian …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …

Enhancers confer precise spatiotemporal patterns of gene expression in response to
developmental and environmental stimuli. Over the last decade, the transcription of …

The maternal-to-zygotic transition (MZT) is a key developmental process in metazoan
embryos that involves the activation of zygotic transcription (ZGA) and degradation of …

Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …

Genome‐wide transcriptional activity involves the binding of many transcription factors (TFs)
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …

Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …

In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …

Background Early embryonic developmental programs are guided by the coordinated
interplay between maternally inherited and zygotically manufactured RNAs and proteins …