Chromatin accessibility: methods, mechanisms, and biological insights
AR Mansisidor, VI Risca - Nucleus, 2022 - Taylor & Francis
Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …
OBOX regulates mouse zygotic genome activation and early development
Zygotic genome activation (ZGA) activates the quiescent genome to enable the maternal-to-
zygotic transition,. However, the identity of transcription factors that underlie mammalian …
zygotic transition,. However, the identity of transcription factors that underlie mammalian …
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos
Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …
Enhancer RNAs step forward: new insights into enhancer function
LJ Harrison, D Bose - Development, 2022 - journals.biologists.com
Enhancers confer precise spatiotemporal patterns of gene expression in response to
developmental and environmental stimuli. Over the last decade, the transcription of …
developmental and environmental stimuli. Over the last decade, the transcription of …
[HTML][HTML] SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis
P Bhat, LE Cabrera-Quio, VA Herzog, N Fasching… - Cell Reports, 2023 - cell.com
The maternal-to-zygotic transition (MZT) is a key developmental process in metazoan
embryos that involves the activation of zygotic transcription (ZGA) and degradation of …
embryos that involves the activation of zygotic transcription (ZGA) and degradation of …
[HTML][HTML] Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation
Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …
and RNAs. However, it remains unclear whether composition, structure, and permeability of …
Pioneer activity distinguishes activating from non‐activating SOX2 binding sites
M Maresca, T van den Brand, H Li, H Teunissen… - The EMBO …, 2023 - embopress.org
Genome‐wide transcriptional activity involves the binding of many transcription factors (TFs)
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity
Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …
known about the role of chromatin factors during this process. Here, we used an in vivo RNA …
[HTML][HTML] The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation
Y Hadzhiev, L Wheatley, L Cooper, F Ansaloni… - Developmental cell, 2023 - cell.com
In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …
blastula transition. However, some genes escape global genome repression, are activated …
[HTML][HTML] miR-430 regulates zygotic mRNA during zebrafish embryogenesis
D Baia Amaral, R Egidy, A Perera, AA Bazzini - Genome Biology, 2024 - Springer
Background Early embryonic developmental programs are guided by the coordinated
interplay between maternally inherited and zygotically manufactured RNAs and proteins …
interplay between maternally inherited and zygotically manufactured RNAs and proteins …