Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

The aryl hydrocarbon receptor (AhR) is a transcriptional factor that regulates multiple
functions following its activation by a variety of ligands, including xenobiotics, natural …

Abstract Di-2-ethylhexyl phthalate (DEHP) has been widely used in many fields (agricultural
products, medical instruments, and food packing). As an environmental contaminant, DEHP …

A variety of experimental and epidemiological studies lend support to the Developmental
Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for …

Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

Polystyrene nanoparticles (PS‐NPs) as an issue of global environmental concern, have
been shown to induce hepatic toxicity via triggering oxidative injury and inflammation. Non …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing
rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most …

The aryl hydrocarbon receptor (AHR) is a transcription factor with roles in detoxification,
development, immune response, chronic kidney disease and other syndromes. It regulates …

Purpose Fatty liver disease (FLD) affects over 25% of the global population and may lead to
liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and …

A large group of polyhalogenated compounds has been added to the list of persistent
organic pollutants in a global convention endorsed by over 100 nations. Once entering the …