Nitrogen-containing heterocyclic rings are common structural components of marketed
drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide …

Therapy based on Bruton's tyrosine kinase (BTK) inhibitors one of the major treatment
options currently recommended for lymphoma patients. The first generation of BTK inhibitor …

Bruton tyrosine kinase (BTK) is a key kinase in the B cell antigen receptor signal
transduction pathway, which is involved in the regulation of the proliferation, differentiation …

Impacting the lives of millions throughout the globe, cancer is the world's leading cause of
death. In cancer treatment and prognosis, a number of anticancer medicines have been …

Protein kinases constitute the largest group within the kinase family, and mutations and
translocations of protein kinases due to genetic alterations are intimately linked to the …

We report 31 new compounds designed, synthesized and evaluated on Bcr-Abl, BTK and
FLT3-ITD as part of our program to develop 2, 6, 9-trisubstituted purine derivatives as …

Chronic myelogenous leukemia (CML) is a malignant myeloproliferative disease. According
to the American Cancer Society's 2021 cancer data report, new cases of CML account for …

Aberrant activation of the Hedgehog (Hh) signalling pathway has been associated with the
development and progression of pancreatic cancer. For this reason, blockade of Hh pathway …

In this work, a series of 30 new 2, 6, 9-trisubstituted purine derivatives were synthesised and
evaluated in silico as potential ligands of the Smoothened (SMO) receptor, as well as their …

Abstract A facile conversion of 6‐(2‐arylidenehydrazineyl) purines to [1, 2, 4] triazolo [3, 4‐i]
purines is presented using PhI (OAc) 2 as oxidant in only 10 min under room temperature …